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Glutathione is not an essential nutrient since it can be synthesized from the amino acids L-cysteine, L-glutamic acid and glycine. The sulfhydryl (thiol) group (SH) of cysteine serves as a proton donor and is responsible for the biological activity of glutathione. Provision of this amino acid is the rate-limiting factor in glutathione synthesis by the cells since cysteine is relatively rare in foodstuffs. Furthermore, if released as the free amino acid, cysteine is toxic and spontaneously catabolized in the gastrointestinal tract and blood plasma.[4]

Glutathione is synthesized in two adenosine triphosphate-dependent steps

Animal and insect glutamate cysteine ligase (GCL) is a heterodimeric enzyme composed of a catalytic (GCLC) and modulatory (GCLM) subunit. GCLC constitutes all the enzymatic activity, whereas GCLM increases the catalytic efficiency of GCLC. Mice lacking GCLC (i.e., all de novo GSH synthesis) die before birth.[5] Mice lacking GCLM demonstrate no outward phenotype, but exhibit marked decrease in GSH and increased sensitivity to toxic insults.[6][7][8]

Glutathione Subcategories

Glutathione Articles

Glutathione - What Are The Best Ways To Raise It, and What Doesn't Work?
by Laura McCallum
Oct 12, 2009
To raise glutathione, there are many ways that have been clinically studied and proven to do so. These fall into the categories of pharmaceuticals or drugs, and natural products. There are also many advertised ways that will not raise your glutathion...

Glutathione - How Does It Help With Detoxification?
by Laura McCallum
Oct 12, 2009
Many are concerned about the toxic chemicals surrounding us in our environment today. How does glutathione help us with detoxification? Find out here!

Detoxification or detox is defined as the removal of toxins from the body. Toxins are con...

Glutathione - Your Body's Own Master Antioxidant
by Laura McCallum
Oct 12, 2009
What are antioxidants, and why is glutathione such an important one? What is oxidative stress, and how does glutathione protect me from this?

How is glutathione your body's very own antioxidant?

Antioxidants are your solution to oxida...

Do You Know - Foods That Help Prevent Wrinkles Can Be Found Right In Your Kitchen
by Ethan Clark
Sep 12, 2009
Alright so you are also like me and hundred others who rely on food that help prevent wrinkles rather than rely on botox or chemotherapy. Good to know that we share the same thought and believe that prevention is better than cure. Most people do not ...

Some Reasons to Use L-Glutathione
by Alicia McWilliams
Aug 27, 2009
As you learn more about the role of l-glutathione in metabolic processes, you may feel that it is very important to find ways to boost its production in your own body. Regardless of your age, chances are, you will be able to benefit from raising cell...

Healthy People Know About Glutathione Health Benefits
by Roberta Warner
Aug 03, 2009
Modern research has proven that individuals who have low levels of glutathione are at the mercy of chronic illness. Reduced levels of glutathione can be caused by continual stress on the immune reaction. As we now know, a lowered immune system can ...

IMMUNE SYSTEM BOOSTERS:What's [J] Got To Do With It?
by Daniel Malfara
Jun 19, 2009
This article contains a message that can result in your prolonged wellness. Do you remember learning about the word entropy some time back in your school years? It is the natural tendency for things to return to a state of chaos. For example, you wee...

The Health Benefits of Glutathione
by John Binns
Jun 16, 2009
Glutathione is a molecular structure of amino acids that occurs naturally in the body. Its purpose is to help in the ability of the body to maintain immunity to infection and illness, as well as acting as an antioxidant agent when the so-called free ...

Judging the Weight Loss Product MaxWLX
by John Binns
Jun 16, 2009
There are enough weight loss products on the market today to make a person’s head spin. This is understandable, due to the alarming increase of obesity and its very dangerous by-product, diabetes, that is affecting millions of people every day. Proposal of Introducing Stress Relieving Techniques in Treatment of Radiation Biohazard
by Aditi Sengupta
Jun 15, 2009
Classifying Radiation: 1.Electromagnetic radiation Examples: ultraviolet, visible light, x-rays, gamma rays Key features: No mass, no charge 2. Particulate radiation Examples: alpha particles, beta particles, neutrons ...

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